Executing malware samples correctly is a complex task. Malware can be embedded in complex installers which cannot be automated.
Malware might be executed only if a specific button in a Microsoft Office document is clicked.
You can use Live Interaction to solve this problem.
The Live Interaction option will provide you (one session per analysis) access to the analysis machine via VNC.
Once connected you can manually execute a malware sample (PE file, Document, URL, etc) via keyboard or mouse input.
You hereby acknowledge to only use the Live Interaction option to start malware samples or simulate user behavior (e.g. click on security dialogs, activate macros, etc).